Discover the convenience and charm of traveling to Fort Madison via Amtrak! Hop aboard the Southwest Chief, a renowned route connecting Chicago to Los Angeles, with stops in Fort Madison twice daily. Arrive at our historic 1910 Santa Fe Depot nestled in downtown Fort Madison, offering a captivating glimpse into the city's past along the picturesque Mississippi Riverfront. Experience seamless travel and immerse yourself in the rich heritage of our vibrant destination with Amtrak. Plan your journey today!